Summary
In this podcast episode, Dr. Judith Campisi discusses how the biological process of aging is linked to molecular and cellular changes, such as the accumulation of senescent cells and loss of mitochondrial function. Cellular senescence is a stress response that occurs to protect individuals from cancer, but the presence of senescent cells could cause more cellular senescence and inflammation in the body. The accumulation of senescent cells could cause tissue destruction and degeneration due to the chronic inflammation caused by these cells. However, researchers have found that selectively causing senescent cells to die could lead to health benefits and that prototype drugs are available. Senescent cells can also be found in the brain and lead to increased inflammation.
The podcast episode discusses the different factors that contribute to cellular senescence, including DNA damage and metabolic imbalances. Lifestyle factors, such as exercise and vitamin D intake, have shown an impact on cellular senescence. There is still much to learn about this process, but the importance of taking proactive steps towards promoting a healthy lifestyle to mitigate the accumulation of senescent cells and associated age-related diseases is emphasized. Certain therapies, such as senolytics and intermittent fasting, have been shown to reduce senescent cells and improve healthspan. Additionally, the impact of NAD levels and precursors like nicotinamide riboside on senescence is discussed. The podcast concludes by highlighting Dr. Campisi's personal lifestyle practices that incorporate moderate exercise and a healthy diet.
