Morgan Levine, PhD, on PhenoAge and the Epigenetics of Age Acceleration — can we change the pace?
Summary

In this podcast episode, Dr. Morgan Levine, an assistant professor at Yale, explains the role of epigenetic clocks and their importance in quantifying biological aging. These clocks can be used to measure aging in almost any tissue type and can predict mortality risk accurately. However, Dr. Levine warns that we are still in the early stages of understanding epigenetic clocks and their limitations. Exercise and a plant-based diet are two lifestyle interventions that can slow the aging process, and the potential for age reversal through partial reprogramming is discussed. The episode also focuses on the role of inflammation and omega-3 fatty acids in aging and disease, and the reliability and validity of consumer-available epigenetic age tests. Dr. Levine is excited about further exploring the basic science of epigenetic changes and understanding the driving forces behind them.