The podcast episode features Lance Armstrong, a former professional cyclist, discussing various aspects of his life and career. He talks about his childhood in Plano, Texas, and his early years as a triathlete before transitioning to full-time cycling. Armstrong also discusses his experience with doping in cycling, including the use of performance-enhancing drugs like EPO and blood transfusions. He reflects on his battle with testicular cancer and the creation of his foundation, Livestrong, to raise awareness about the disease. Armstrong also talks about his experience during the Tour de France and his rivalry with other cyclists. The conversation ends with Armstrong reflecting on his life and acknowledging the mistakes he has made.