Summary
In celebration of their 200th episode, The Drive podcast revisits topics covered in the last 100 episodes, discussing changes in viewpoints on cancer screening and therapeutics, atherosclerotic cardiovascular disease, Alzheimer's disease genetics, nutrition, fasting, protein consumption, psychedelics, exercise, sleep, and supplements. The host emphasizes the importance of having strong convictions but being willing to adjust them with new information. The speaker discusses the promise of immunotherapy in cancer treatment and the use of till or adaptive cell therapy to expand T cells and eradicate tumors. The speaker also talks about the importance of screening for gastrointestinal cancers, especially colon cancer, and the leading causes of atherosclerotic cardiovascular disease (ASCVD).
The podcast also discusses the importance of lowering ApoB levels to prevent ASCVD and the importance of looking at genes outside of ApoE in relation to Alzheimer's disease. The host questions the benefits of time-restricted feeding and suggests that the main benefit is caloric restriction. They recommend getting a DEXA scan to measure body composition and emphasize the importance of exercise for longevity and health span, particularly strength training to build muscle mass. The speaker discusses the potential benefits of nad precursors nr and nmn in increasing nad levels, but cautions that there is currently no evidence of any phenotypic benefit for normal or aging individuals.
The podcast also discusses sleep aids, noting that trazodone is a good option for most people due to its ability to preserve sleep architecture without producing dependency issues. The use of electronics before bed may not be as detrimental to sleep as previously thought. The hosts also introduce Formula One racing for those who are unfamiliar with the sport, discussing the complexities of the sport and the importance of strategy in determining the winner of a race. The article describes the importance of qualifying in Formula 1 racing and how it impacts the outcome of the race. The schedule for an F1 weekend is outlined, including the purpose of the free practice sessions and qualifying.
