The podcast episode titled "What is a Concussion?" features conversations between the hosts and various guests about the impact of head injuries in sports, specifically football. The guests include former NFL player Leonard Marshall, neuroscientist Heather Berlin, and doctors Anne McKee and Robert Cantu. The discussions cover a range of topics related to concussions and chronic traumatic encephalopathy (CTE), such as the accumulation of smaller traumas leading to CTE, the limitations of diagnosing CTE in living individuals, the neurochemical cascade that occurs during a traumatic injury, and the importance of reducing contact in sports while still maintaining excitement. The hosts also touch on the potential long-term damage caused by playing sports and the need to prioritize brain health in addition to physical health. Overall, the episode sheds light on the ongoing debate surrounding the long-term effects of playing football and the responsibility of sports organizations to protect their players.