The Huberman Lab podcast episode discusses the importance of breathing and its impact on mental and physical health. The respiratory system has mechanical and chemical components, including the nose, mouth, lungs, diaphragm, intercostal muscles, and bloodstream. Correct breathing involves balancing oxygen and carbon dioxide levels, and over-breathing can lead to hypoxia and panic attacks. The podcast emphasizes the importance of nasal breathing and pauses between breaths, and provides tools and techniques for breathing correctly, including the physiological sigh and box breathing. The podcast also explores the relationship between breathing and heart rate and discusses the benefits of rhythmic breathing for reducing stress and improving cognitive function. The episode concludes with a call to action for subscribing to the podcast and following the speaker on social media.