Summary
In this episode of The Huberman Lab Podcast, the host, Andrew Huberman, discusses the impact of hormones on feeding, hunger, and satiety. He explains that the ventromedial hypothalamus and the insular cortex are two brain areas involved in regulating hunger and feeding. The host also talks about two hormones related to hunger: MSH and ghrelin. MSH is a hormone that inhibits hunger and can be controlled through viewing ultraviolet light, while ghrelin is a hormone that activates hunger and is released from the GI tract. The speaker provides tips on how to shift your feeding schedule and discusses the importance of controlling blood sugar levels and the benefits of intermittent fasting.
The podcast also covers the interplay between brain and body when it comes to regulating appetite. The speaker discusses the hormone CCK, which is released from the GI tract and can suppress appetite when triggered by fatty acids, amino acids, or sugars. The gut is constantly assessing levels of these micronutrients and sending signals to the brain to regulate appetite. The host also talks about the negative impact of highly processed foods on the gut and the gut-brain axis, recommending avoiding highly processed foods and switching to whole foods for better health.
The podcast also discusses the importance of managing glucose levels in the body, particularly for individuals with diabetes. The insulin system manages glucose levels, while the glucagon system pulls energy from the liver and muscles for immediate fuel. The speaker explains that the order in which foods are consumed has a significant impact on blood glucose levels, with carbohydrates and fats causing a steep rise and fibrous vegetables blunting the increase. Movement, particularly exercise, can also help regulate blood glucose levels.
Lastly, the podcast discusses the effects of various supplements and compounds on blood glucose levels. Berberine, a compound found in tree bark, has been shown to have strong effects in lowering blood glucose levels, but dosages and side effects vary. Other supplements such as chromium, L-carnitine, and Panax ginseng have minor effects on reducing blood glucose levels. Caffeine has been shown to increase blood glucose levels slightly, while magnesium and zinc can modestly reduce blood glucose levels. The host also talks about the history of understanding diabetes and how physicians in ancient times used ants to diagnose high blood glucose levels in patients.
